cytotoxic effects of essential oils and extracts of some mentha species on vero, hela and hep2 cell lines

نویسندگان

n rahimifard department of microbiology, food and drug laboratory research center (fdlrc), moh & me

h hajimehdipoor traditional medicine and materia medica research center and department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran tel & fax: +98 – 21 - 88776027

mh hedayati department of biotechnology, pasture institute of iran

o bagheri molecular biotechnology research center, baqiatalah university of medical sciences

چکیده

background: mentha species are widely used in traditional medicine mostly as anti-flatulence. nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. moreover, cytotoxic effects of some mentha species have been reported. objective: in this study, cytotoxic properties of mentha piperita, m. spicata, m. aquatica, m. crispa, m. pulegium and m. longifolia have been investigated. methods: different concentrations of essential oils and total extracts of six mentha species were tested by mtt assay against vero, hep2 and hela cell lines. results: the results showed that all samples were toxic against vero, hela and hep2 cell lines (ic50 28.1-166.2 µg/ml). conclusion: all examined mentha species extracts and essential oils have cytotoxic effects but some of them could be considered as potent toxic agents.

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فصلنامه علمی پژوهشی گیاهان دارویی

جلد ۳، شماره ۳۵، صفحات ۸۸-۹۲

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